The Real Problem With The GOP

January 14, 2011 - One-year anniversary of the Internet radio program with Driftglass and Bluegal!

Download the MP3 (39:25)

Description: Anniversary program - The real problem with the GOP, why mere civility and facts are not enough to move the dialogue forward, and a historical explanation of why "blood libel" is a perfect motif for conservative political discourse.

You can listen to the archives at http://professionalleft.blogspot.com/

New Therapies for Prevention and Treatment of Alzheimer's Disease Identified

Alzheimer's disease is the leading cause of severe memory loss late in life and the fourth leading cause of death in adults, after heart disease, cancer and stroke. The National Institute on Aging estimates that over 4 million people in the United States suffer from the disease.

For too long there is no cure for Alzheimer's disease, no known way to prevent the illness, and the benefits of current treatments are modest at best. Those afflicted with Alzheimer's disease and their families, lacking effective treatments, must deal with the grueling realities of the disease over time. Alzheimer's disease is called the disease of the "long goodbye" because as it steals memory, cognitive function, and even personality over a period of five to eight years, it is as though the person dies several times over. One day a parent with Alzheimer's disease may recognize their child and next day treat the child as suspicious stranger. Families face only frank acknowledgment of the difficult choices the about the value and the quality of life for a parent diagnosed with Alzheimer's disease during the "long goodbye."

Perhaps, finally, there is now a glimmer of hope that medical researchers may have found the true path of understanding and curing this dread disease:

ScienceDaily (Jan. 14, 2011) — A Blanchette Rockefeller Neurosciences Institute (BRNI) study published in the Journal of Neuroscience reveals underlying causes for the degeneration of synapses in Alzheimer's Disease and identifies promising pharmaceutical solutions for the devastating condition that affects more than 5 million people in the United States. The BRNI study is the first to achieve fundamental molecular understanding of how synapses are lost in Alzheimer's Disease before the plaques and tangles develop. At the same time, it is the first study to demonstrate the comprehensive benefits of synaptogenic compounds in treating Alzheimer's Disease.

The BRNI study marks an important shift in our understanding of how Alzheimer's Disease is caused and should be treated. Previous autopsy-based studies have shown the critical role of synaptic loss in producing dementia (though, not the reason behind the degeneration), yet for decades scientists and pharmaceutical companies have focused on ways to target the amyloid plaques and neurofibrillary tangles thought to play a role in causing Alzheimer's Disease. By preventing the loss of synapses, BRNI's new therapeutics prevent the progressive symptoms of Alzheimer's Disease.

"Alzheimer's Disease is not primarily a disease of plaques and tangles as many had previously concluded, it is most importantly a disease of synapses," said Dr. Daniel Alkon, the scientific director of BRNI and co-author of the study, "This study found that treatments that target the loss of synapses in the Alzheimer's brain, can virtually eliminate all other elements of the disease -- elevation of the toxic protein, A Beta, the loss of neurons, the appearance of plaques, and loss of cognitive function; the animals' brains were normalized."

The study utilized mice genetically engineered to express the symptoms and pathology of human Alzheimer's Disease in two different strains. BRNI used a difficult training regimen for the mice in order to reveal that significant cognitive deficits occurred five months before plaques were detected in their brains, providing evidence that plaques and tangles are not at the root of the disease.

Treatments of Bryostatin and similar compounds synthesized at BRNI that target the enzyme PKCε, which controls the creation of synapses at the molecular level, were administered for twelve weeks during the study. While the compounds promoted the growth of new synapses and preservation of existing synapses, they also stopped the decrease of PKCε and the increase of soluble β amyloid, meaning that the treatments could be used to prevent the familiar hallmarks of Alzheimer's Disease, the plaques and tangles. BRNI has received approval to move forward with Phase II clinical testing for Bryostatin to treat Alzheimer's Disease, which is set to begin within the next several months.

The synaptogenic BRNI drugs have also shown potential for the treatment of traumatic brain injury (TBI), as recently reported in the journal Neurobiology of Disease, and stroke described in the Proceedings of the National Academy of Science in 2008 and 2009.

The target of the synaptogenic compounds is the same molecule identified as a biomarker for early diagnosis of Alzheimer's Disease in clinical trials conducted by BRNI and published in Neurobiology of Aging in 2010. As a result of that study, researchers at the Institute are now working to develop a skin test for identifying Alzheimer's Disease in its early stages before significant progression.

TX-Sen: Kay Bailey Hutchison Announces She Won't Run for Re-Election in 2012

From the Dallas Morning News:

“I have known since 2006 that I wouldn’t seek another term,” the senator said in a telephone interview. “I wanted to announce it on my own terms and in my own way."

Hutchison, first elected to the Senate in 1993, said the swearing-in of the new Congress, among other things, made her feel it was the right moment to announce her resignation.

Obama's Arizona Speech: 'I Want America To Be As Good As She Imagined It'

President Barack Obama implored Americans to honor those slain and injured in the Arizona shootings by becoming better people, telling a polarized citizenry that it is time to talk with each other "in a way that heals, not in a way that wounds."

Visit msnbc.com for breaking news and world news

MOMocrats Blog Talk Radio - 01/12/2011

Listen to MOMocrats talk about the attempted assassination of U.S. Rep. from Arizona Gabrielle Giffords Jan 12 2011

Daily Show: Arizona Shootings Reaction

The Daily Show With Jon Stewart - Arizona Shootings Reaction Stewart's comments reflect the sentiments of the editorial board of this blog.

Texas Budget Deficit at $27 Billion, Says Texas Comptroller Susan Combs

Texas is expected to collect $72.2 billion in taxes, fees and other general revenue during the 2012-13 budget, down from the $87 billion used in the current two-year budget, Comptroller Susan Combs announced Monday.

That puts the shortfall at $27 billion given that maintaining services would run $99 billion for biennium.

Combs’ estimate dictates how much the Legislature will have to spend in the upcoming budget on education, prisons, health and human services and a slew of other state functions.

Even with the $9.4 billion rainy day fund, the state would still not have enough to maintain services at their current levels, which would run $99 billion according to agency budget requests.

Though Texas is facing a budget shortfall of roughly the same magnitude as California, it has gotten nearly no notice in the mainstream press, and at this point, there’s practically nothing left in the state’s budget to cut besides public safety, education and health care spending (while Texas already has some of the lowest per-pupil spending rates and the highest number of those without health insurance).

In September, Gov. Rick Perry guessed the state was facing a $10-11 billion budget shortfall for its fiscal 2012-2013 budget, and refused serious comment on reports that his budget gap might be larger. Not only did Perry severely underestimate the depth of his state’s budget woes, but he has also spent the last few years lecturing Washington D.C. on its supposed fiscal improprieties, giving speech after speech in which he held up Texas as the economic model for the nation to follow. Just last week, he said that Congress needs to propose a balanced budget amendment to the Constitution, or else “the hard work that Texas and states like ours have done to make prudent fiscal decisions will be washed away by Washington’s growing avalanche of excess”:

“I am convinced that a constitutional limit on Washington’s spending sprees and irresponsible borrowing is the only boundary they will understand and heed. Otherwise, the hard work that Texas and states like ours have done to make prudent fiscal decisions will be washed away by Washington’s growing avalanche of excess.” [Source]

“Americans are growing ever more aware of this spending explosion, and increasingly interested in grabbing the throttle, so they can slow down Washington’s runaway train. I’m convinced that the hardworking citizens of our state and country simply want government to handle the basics, then get out of the way, as we have done here in Texas.” [Source]

“I don’t suspect I’m the only person in this room who is concerned about a national debt that has blown past $11 trillion and a federal deficit that is well over $1 trillion… Fortunately, we have taken the opposite approach here in Texas.” [Source]

“In Texas and South Carolina, we’ve focused on improving “soil conditions” for businesses by cutting taxes, reforming our legal system and our workers’ compensation system. We’d humbly suggest that Congress take a page from those playbooks by focusing on targeted tax relief paid for by cutting spending, not by borrowing.” [Source]

As Paul Krugman wrote in a NYTime OpEd, “Texas is where the modern conservative theory of budgeting — the belief that you should never raise taxes under any circumstances, that you can always balance the budget by cutting wasteful spending — has been implemented most completely. If the theory can’t make it in Texas were Republicans have dominated state government for more than a decade, it can’t make it anywhere.” And it seems the theory can’t make it there.

Click here to read the comptroller’s report (PDF)

Between A Rock And A Hard Place

Cross post from the West Texas Jobsanger blog
by Ted McLaughlin

The building pictured right is the capitol building of the State of Texas. It will once again be a bustling place starting on Tuesday, January 11th, when the legislature meets for its biennial session (unlike most other states, the Texas legislature only meets once every two years -- on the second Tuesday of each odd-numbered year).

This is also the week that the state's comptroller gives her official verdict on what the state's budget looks like for the next two years. And it is expected that the legislature will find themselves, as my grandmother used to say, between a rock and a hard place. The comptroller is expected to announce that the state will have a budget shortfall of between $21 and $25 billion dollars -- a huge deficit for a total budget of around $95 billion dollars.

Even knowing they would have a huge budget shortfall to face in this legislative session the Republicans campaigned on a platform of no new taxes. They promised voters that they could fix the deficit with cuts to government services alone -- cuts that would not damage the necessary services delivered by government. It was a promise that will be impossible to keep, but the voters fell for it and gave the Republicans huge majorities in both houses of the legislature.

To keep their promise the Republicans would have to cut all state agencies and other state outlays by about 26%. This is in addition to a couple of 10% cuts that have already been done and a 5% cut that is currently underway. It doesn't take a genius to figure out that there is no way the services delivered by the state's agencies can survive such a massive cut (on top of the cuts already done). Services will suffer, and in some cases may disappear altogether. In addition, the state's schools would be in serious trouble if the state contribution to education was cut by such a massive amount.

The three biggest items in the state budget are criminal justice (Department of Criminal Justice, Texas Youth Commission, Department of Public Safety, etc.), education (elementary & high schools, higher education, etc.) and human services (AFDC, Medicaid, Food Stamps, Child Protective Services, Adult Protective Services, etc.). Since these are the biggest items in the budget, then it makes sense that they would have to suffer the biggest cuts.

That's not going to be easy though. Cuts to criminal justice is not going to be popular with the public. It will mean thousands of criminals being dumped back into the communities with little or no supervision and no help to find jobs (which don't exist anyway) or programs to help with drug and alcohol problems (also severely cut by the state). A Republican legislature is not going to like the public uproar this will create.

Cuts to human services will also be hard to do. Cuts to programs partially funded by the federal government, like Medicaid or Food Stamps, would result in a loss of federal funds and put the state in an even bigger financial bind. And cuts to programs like Child or Adult Protective Services will just result in more children and elderly Texans being abused and mistreated (the kind of things guaranteed to make negative headlines and public outrage).

Education is even tougher. Texas already ranks near the bottom of all states in the amount of money it provides for education per pupil. And considering that the dropout rate is near 30% for Texas high schools, it would seem outrageous that cuts to education would be on the table for legislative consideration -- but they are. It would seem that tax cuts for wealthy Texans is more important than the education of Texas students.

Making matters even worse for the Republican legislature is the fact that although they were elected on a platform of not raising taxes, a new newspaper poll shows significant majorities of Texas citizens are opposed to cuts in education and human services. The survey, conducted by Blum & Weprin Associates for several newspapers, shows that 70% of the public opposes any cuts to education (high schools and elementary schools). Although 53% would allow cuts to higher education, only 11% would approve of large cuts even there.

And Texans are not much more responsive to cuts in human services. About 62% of Texans oppose cuts in health care to children or low-to-moderate-income families.

This definitely puts the legislature in a difficult predicament. Although elected on a promise not to raise taxes, the public definitely opposes significant cuts in the parts of the budget that contains the most spending. They can either make the public mad by raising taxes or make the public mad by cutting necessary and popular programs. And either way, the Republicans must shoulder the blame since they have the governor's office and huge majorities in both houses.

I suspect they will do a little of both -- cut the budget and raise taxes. But they will raise taxes in a sneaky way so they can have some deniability -- such as broadening the sales tax base to include items now exempt instead of raising the tax rate, and raising the fees for many services like driver's licenses, marriage licenses and hunting licenses. They will then claim they kept their word since a fee is not a tax. It's not true of course, but that's what they'll claim anyway. There's only one thing we can be sure of -- taxes and fees on corporations and the rich will not be raised. Texas has the most regressive taxes in the nation and that will stay the same.

This dog-and-pony show will start on Tuesday, and it should be interesting to see how the Republicans get themselves out of the mess they have created with their past actions. The only good thing is that this time they can't blame the Democrats for their own actions.

Related:

• One Huge State Budget Crisis That Everyone Refuses To Talk About

Political World Stunned By AZ Congresswoman's Shooting

TUCSON, Ariz. – Rep. Gabrielle Giffords (D) of Arizona was shot in the head Saturday by a gunman who opened fire outside a grocery store during a meeting with voters, killing a federal judge and five others, including one 9 year old child who was born on 9/11/2001. Giffords was reportedly shot in the head after a man approached the event and began firing, also hitting 18 other people, including three of Giffords staffers. Rep. Giffords is one of 20 Democratic lawmakers targeted with gun cross hairs on Sarah Palin's political action committee map of the US.

In Sheriff Clarence Dupnik’s press conference tonight, he said that law enforcement are “actively in pursuit” of a second suspect in the shooting.

President Obama called the shooting an "unspeakable tragedy." "We do not yet have all the answers," he said in a statement. "What we do know is that such a senseless and terrible act of violence has no place in a free society."

Pima County Sheriff Clarence Dupnik said Giffords was the target of a gunman whom he described as mentally unstable and possibly acting along with an accomplice. He said Giffords was among 13 people wounded in the melee that killed six people, including Arizona's chief federal judge, a 9-year-old girl and an aide for the Democratic lawmaker. He said the rampage ended only after two people tackled the gunman.

Doctors were optimistic about Giffords surviving as she was responding to commands from doctors despite having a bullet go through her head. "With guarded optimism, I hope she will survive, but this is a very devastating wound," said Dr. Richard Carmona, the former surgeon general who lives in Tucson.

The sheriff pointed to the vitriolic political rhetoric that has consumed the country as he denounced the shooting that claimed several of his friends as victims, including U.S. District Judge John Roll. The judge celebrated Mass on Saturday morning like he does every day before stopping by to say hello to his good friend Giffords.

"When you look at unbalanced people, how they respond to the vitriol that comes out of certain mouths about tearing down the government. The anger, the hatred, the bigotry that goes on in this country is getting to be outrageous," the sheriff said. "And unfortunately, Arizona I think has become the capital. We have become the mecca for prejudice and bigotry."

After Giffords voted in favor of the health-care overhaul in March, she said that vandals had broken the glass door of her Tucson office. "The rhetoric is incredibly heated, not just the calls but the emails, the slurs," she told MSNBC at the time. "Things have really gotten spun up." She added: "We do have these polarized parts of our parties that really get excited, and that's where ... all of us have to come together and say, 'OK, there's a fine line here.' "

That same month, Sarah Palin's political action committee posted a map of the US, showing the locations of the 20 Democratic members of Congress, including Giffords, it was targeting for defeat. Each location was marked by an image of a gun cross hairs.

Palin's camp dismissed charges that she was encouraging acts of violence, saying she had spoken out against violence. But Giffords herself was one of many who spoke out against the image, telling MSNBC: "When people do that, they've gotta realize there's consequences to that action."

Palin, who has never publicly advocated violence against fellow US politicians, has often employed "lock and load" rhetorical attacks that leverage imagery and terminology familiar to gun owners and evocative of firearms. She said last March that her supporters should "reload" and "aim for" Democrats, ostensibly with their votes.

Jesse Kelly, Giffords' Republican opponent in the 2010 mid-term elections, similarly employed guns in a campaign event. He staged an event in July asking supporters to "get on target" and "remove Gabrielle Giffords from office" -- all while shooting "a fully automatic M16 with Jesse Kelly."

Huffingtonpost: Rep. Raul Grijalva (D-Ariz.), who represents a district adjacent to Gabrielle Giffords's, said that Saturday's shooting is a consequence of the vitriolic rhetoric that has arisen over the past few years among extreme elements of the Tea Party. "The climate has gotten so toxic in our political discourse, setting up for this kind of reaction for too long. It's unfortunate to say that. I hate to say that," Grijalva said in an interview with The Huffington Post. "If you're an opponent, you're a deadly enemy," Grijalva said of the mindset among Arizona extremists. "Anybody who contributed to feeding this monster had better step back and realize they're threatening our form of government."

Keith Olbermann Issues Special Comment On Arizona Shooting: 'Violence Has No Place In Democracy'

The Texas Omen

NYTimes Op-Ed
By PAUL KRUGMAN
Published: January 6, 2011

These are tough times for state governments. Huge deficits loom almost everywhere, from California to New York, from New Jersey to Texas.

Wait — Texas? Wasn’t Texas supposed to be thriving even as the rest of America suffered? Didn’t its governor declare, during his re-election campaign, that “we have billions in surplus”? Yes, it was, and yes, he did. But reality has now intruded, in the form of a deficit expected to run as high as $25 billion over the next two years.

And that reality has implications for the nation as a whole. For Texas is where the modern conservative theory of budgeting — the belief that you should never raise taxes under any circumstances, that you can always balance the budget by cutting wasteful spending — has been implemented most completely. If the theory can’t make it there, it can’t make it anywhere.

How bad is the Texas deficit?
--- Click here for REST OF STORY!... ---
Related:

• One Huge State Budget Crisis That Everyone Refuses To Talk About